Closed-Loop Deep Brain Stimulation: Optimising Treatment of Parkinson’s Disease Using Adaptive Stimulation

Stimulation artefact removal: review and evaluation of applications in evoked responses

T Zhang, K Lawson, WL Lee, M Petoe, A Moorhead, K Bulluss, W Thevathasan, H McDermott, T Perera

2024-12-01

Objective. This study investigated software methods for removing stimulation artefacts in recordings undertaken during deep brain ..

Detection of evoked resonant neural activity in Parkinson's disease

Wee-Lih Lee, Nicole Ward, Matthew Petoe, Ashton Moorhead, Kiaran Lawson, San San Xu, Kristian Bulluss, Wesley Thevathasan, Hugh McDermott, Thushara Perera

2024-02-01

Objective. This study investigated a machine-learning approach to detect the presence of evoked resonant neural activity (ERNA) re..

Anatomical targeting for electrode localization in subthalamic nucleus deep brain stimulation: A comparative study

T Tonroe, H McDermott, P Pearce, N Acevedo, W Thevathasan, SS Xu, K Bulluss, T Perera

2023-09-01

Background and Purpose: In deep brain stimulation (DBS), accurate electrode placement is essential for optimizing patient outcomes..

Electrically evoked and spontaneous neural activity in the subthalamic nucleus under general anesthesia

NC Sinclair, HJ McDermott, WL Lee, SS Xu, N Acevedo, A Begg, T Perera, W Thevathasan, KJ Bulluss

2022-08-01

OBJECTIVE Deep brain stimulation (DBS) surgery is commonly performed with the patient awake to facilitate assessments of electrode..

Lesser-Known Aspects of Deep Brain Stimulation for Parkinson's Disease: Programming Sessions, Hardware Surgeries, Residential Care Admissions, and Deaths

SS Xu, CB Malpas, KJ Bulluss, HJ McDermott, T Kalincik, W Thevathasan

2022-08-01

Objective: The long-term treatment burden, duration of community living, and survival of patients with Parkinson's disease (PD) af..

Can brain signals and anatomy refine contact choice for deep brain stimulation in Parkinson's disease?

SS Xu, WL Lee, T Perera, NC Sinclair, KJ Bulluss, HJ McDermott, W Thevathasan

2022-05-19

Introduction Selecting the ideal contact to apply subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease is t..

Towards guided and automated programming of subthalamic area stimulation in Parkinson's disease

SS Xu, NC Sinclair, KJ Bulluss, T Perera, WL Lee, HJ Mcdermott, W Thevathasan

2022-01-01

Selecting the ideal contact to apply subthalamic nucleus deep brain stimulation in Parkinson's disease can be an arduous process, ..

How accurately are subthalamic nucleus electrodes implanted relative to the ideal stimulation location for Parkinson's disease?

P Pearce, K Bulluss, SS Xu, B Kim, M Milicevic, T Perera, W Thevathasan

2021-07-01

Introduction: The efficacy of subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) depends on how cl..

Feedback control for deep brain stimulation for motor disorders

HJ McDermott, NC Sinclair

2020-06-23

Deep brain stimulation (DBS) is an effective treatment for many people living with Parkinson’s disease (PD). Although the primary ..

Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology

A Ramirez-Zamora, J Giordano, A Gunduz, J Alcantara, JN Cagle, S Cernera, P Difuntorum, RS Eisinger, J Gomez, S Long, B Parks, JK Wong, S Chiu, B Patel, WM Grill, HC Walker, SJ Little, R Gilron, G Tinkhauser, W Thevathasan

2020-03-27

The Seventh Annual Deep Brain Stimulation (DBS) Think Tank held on September 8th of 2019 addressed the most current: (1) use and u..

Tailoring Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Using Evoked Resonant Neural Activity

W Thevathasan, NC Sinclair, KJ Bulluss, HJ McDermott

2020-02-28

Deep brain stimulation for Parkinson's disease modulates high-frequency evoked and spontaneous neural activity

NC Sinclair, HJ McDermott, JB Fallon, T Perera, P Brown, KJ Bulluss, W Thevathasan

2019-10-01

Deep brain stimulation is an established therapy for Parkinson's disease; however, its effectiveness is hindered by limited unders..

On the neural basis of deep brain stimulation evoked resonant activity

NC Sinclair, JB Fallon, KJ Bulluss, W Thevathasan, HJ McDermott

2019-08-07

Objective: Deep brain stimulation can be a remarkably effective treatment for Parkinson's disease and other conditions; however, a..

A palm-worn device to quantify rigidity in Parkinson's disease

T Perera, WL Lee, M Jones, JL Tan, EL Proud, A Begg, NC Sinclair, R Peppard, HJ McDermott

2019-04-01

Background: Parkinsonian rigidity is identified on clinical examination as resistance to passive movement. Measurement of rigidity..

Objective evaluation of bradykinesia in Parkinson's disease using an inexpensive marker-less motion tracking system

WL Lee, NC Sinclair, M Jones, JL Tan, EL Proud, R Peppard, HJ McDermott, T Perera

2019-02-01

Objective: Quantification of bradykinesia (slowness of movement) is crucial for the treatment and monitoring of Parkinson's diseas..

Subthalamic nucleus deep brain stimulation evokes resonant neural activity

NC Sinclair, HJ McDermott, KJ Bulluss, JB Fallon, T Perera, SS Xu, P Brown, W Thevathasan

2018-05-01

Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target-speci..